Izumi and her husband Sig Curtis were expecting a child years before the start of the series; however, their son was stillborn. Izumi tried and failed to revive the child through human transmutation (an act that created Wrath in the first anime). The failed attempt took some of her internal organs, resulting in infertility, and causing her to periodically cough up blood. Izumi gained the ability to use alchemy without a transmutation circle after seeing the "truth."
In the manga, Izumi attracts the attention of the State Military for surviving the failed human transmutation. As she and her husband travel around Amestris in order to avoid the military, they eventually meet Ed and Al's father Hohenheim. He rearranges her insides to ease the blood flow, and persuades her to help collaborate in bringing down the State Military.
|Fullmetal Alchemist||Season 1||TV||51||8.37||8.38|
|Fullmetal Alchemist: The Conqueror of Shambala||Movie 1||Movie||1||7.97||7.99|
|Fullmetal Alchemist: Reflections||Recap||Special||1||8.11||8.23|
|Fullmetal Alchemist: Brotherhood||Season 2||TV||64||9||9.03|
|Fullmetal Alchemist: Brotherhood Specials||OVA||4||8.36||8.45|